منابع مشابه
ISN Forefronts Symposium 2015: Nuclear Receptors and Diabetic Nephropathy
Diabetic nephropathy (DN) is the major reason for end stage renal disease in the western world. Patients with DN developed more severe cardiovascular complications with worse prognosis. In spite of tight blood pressure and glucose control through applying angiotensin II receptor antagonism, angiotensin receptor inhibitors and even direct renin inhibitors, the progression and development of DN h...
متن کاملSummary of ISN Forefronts Symposium 2015: ‘Immunomodulation of Cardio-Renal Function’
Xiong Z. Ruan, Youfei Guan, Zhi-Hong Liu, Kai-Uwe Eckardt and Robert Unwin Centre for Nephrology, University College London, London, UK; AstraZeneca-Shenzhen University Joint Institute of Nephrology, Centre for Nephrology & Urology, Shenzhen University Health Science Center, Shenzhen, China; Advanced Institute of Medical Science, Dalian Medical University, Dalian, China; National Clinical Resea...
متن کاملISN Forefronts Symposium 2015: The Diverse Function of Macrophages in Renal Disease
M onocytes and macrophages are key components of the mononuclear phagocyte system. Whereas dendritic cells are specialized for immune surveillance and the activation of the adaptive immune system, macrophages are highly phagocytic cells that are involved in tissue development and homeostasis, inflammation, fibrosis, and tissue repair. Difficulties can arise, however, as there is significant ove...
متن کاملISN Forefronts Symposium 2015: The Evolution of Hypertension–Old Genes, New Concepts
Hypertension is known as the "silent killer," driving the global public health burden of cardiovascular and renal disease. Blood pressure homeostasis is intimately associated with sodium balance and the distribution of sodium between fluid compartments and within tissues. On a population level, most societies consume 10 times more salt that the 0.5 g required by physiological need. This high sa...
متن کاملISN Forefronts Symposium 2015: Maintaining Balance Under Pressure—Hypertension and the Proximal Tubule
Renal control of effective circulating volume is key for circulatory performance. When renal Na+ excretion is inadequate, blood pressure rises and serves as a homeostatic signal to drive natriuresis to re-establish effective circulating volume (ECV). Recognizing that hypertension involves both renal and vascular dysfunction, this report concerns proximal tubule Na+/H+ exchanger 3 (PT NHE3) regu...
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ژورنال
عنوان ژورنال: Nature Clinical Practice Nephrology
سال: 2006
ISSN: 1745-8331,1745-8323
DOI: 10.1038/ncpneph0144